ISSN 1662-4009 (online)

ey0015.10-7 | Continuous glucose monitoring, insulin pumps and artificial pancreas | ESPEYB15

10.7 Closed-loop control during intense prolonged outdoor exercise in adolescents with T1DM: the artificial pancreas ski study

MD Breton , DR Cherñavvsky , GP Forlenza , MD DeBoer , J Robic , RP Wadwa , LH Messer , BP Kovatchev , DM Maahs

To read the full abstract: Diabetes Care. 2017;40:1644-1650Exercise is thought to lead to more stable metabolic control but may also be associated with an increased risk of hypoglycemia. The selection of sport disciplines does not differ between youngsters with diabetes and their healthy siblings. Also, patients with diabetes are not restricted in respect to their sporting activities but seem to enga...

ey0017.8-12 | New Hope | ESPEYB17

8.12. HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

J Zein , B Gaston , P Bazeley , MD DeBoer , RP Jr Igo , ER Bleecker , D Meyers , S Comhair , NV Marozkina , C Cotton , M Patel , M Alyamani , W Xu , WW Busse , WJ Calhoun , V Ortega , GA Hawkins , M Castro , KF Chung , JV Fahy , AM Fitzpatrick , E Israel , NN Jarjour , B Levy , DT Mauger , WC Moore , P Noel , SP Peters , WG Teague , SE Wenzel , SC Erzurum , N Sharifi

To read the full abstract: Proc Natl Acad Sci U S A. 2020; 117(4): 2187–2193. PMID: 31932420.Since their discovery ~70 years ago, glucocorticoids (GC) have been widely used to elicit a systemic anti-inflammatory response, and currently play a major role in the treatment of asthma and other inflammatory diseases (1). However, unresponsiveness to GC in some individuals i...